1 What is Metaglip?

Brand: Metaglip

Generic: Glipizide and Metformin Hydrochloride

Metaglip is a drug used in the treatment of increased blood sugar levels in adults with type 2 diabetes mellitus.

This drug is available as a film-coated tablet containing glipizide 2.5 milligrams and metformin hydrochloride 500 milligrams, glipizide 5 milligrams and metformin hydrochloride 500 milligrams or glipizide 2.5 milligrams and metformin hydrochloride 250 milligrams.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Tell your doctor about prescription/nonprescription drugs and herbal products you may use with Metaglip.

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to glipizide or metformin
  • Kidney disease
  • Liver disease
  • Conditions that may cause a low level of oxygen in the blood or poor circulation (e.g., severe congestive heart failure, recent heart attack, recent stroke)
  • Metabolic acidosis such as in:
  • Serious infection
  • Dehydration
  • Alcohol use
  • Severe breathing problems
  • Blood problems
  • Electrolyte imbalance such as:
  • Fertility problems
  • Certain hormonal conditions such as:
    • Adrenal/Pituitary insufficiency
    • Thyroid disease
    • or Syndrome of inappropriate antidiuretic hormone-SIADH
  • Pregnancy or lactation