1 What is Mysoline?

Brand: Mysoline

Generic: Primidone

Mysoline is a prescription drug used in controlling seizures caused by epilepsy. This drug may be prescribed alone or with other drugs as treatment of epilepsy. An anticonvulsant, primidone targets the brain tissue to stop convulsions or seizure attacks.

2 What to Know Before Using

Your doctor will inform you of what you need to know before using Mysoline. The risks and benefits the medicine offer must be weighed.

Before using this, you and your doctor must consider the following:

  • Allergies: If you have any unusual reaction to any medicine, be sure to tell your doctor about it. Additionally, disclose other types of allergies - food, preservatives, animals, or dyes, if there are any. Read the package ingredients carefully and make sure you are not allergic to any of its ingredients.
  • Pediatric: Studies show that the use of primidone in children does not pose any age-related problems that will limit the medicine’s usefulness.
  • Geriatric: There are no appropriate studies done to show the relationship of age to this medicine’s effects in the elderly. Nonetheless, the elderly are typically more sensitive to the effects of this drug, which may cause them to experience unusual restlessness or excitement.
  • Pregnancy: Using this medicine may be risky to the fetus. The benefits of this drug may be weighed against the risk, in life-threatening situations.
  • Breastfeeding: Although there are no adequate studies in lactating mothers that determine potential risk in infant when breastfeeding, the benefits should be weighed against the risks before taking this medication.
  • Drug Interactions: Certain medicines have adverse effects when used together. Nevertheless, it is still possible to take other medicines when taking primidone. Make sure to inform your doctor about other drugs you are taking, so that alterations and precautions will be made if necessary.Using this medicine with certain medicines needs utmost caution because the combination may result in certain side effects. Using this medicine with other drugs, such as Amifampridine, Atazanavir, Artemether, Boceprevir, Cobicistat, Delavirdine, Delamanid, Elvitegravir, Isavuconazonium Sulfate, Lumefantrine, Lopinavir, Lurasidone, Nisoldipine, Maraviroc, Ritonavir , Rilpivirine, Tipranavir, Telaprevir, and Voriconazole is usually not advisable, but may be needed in certain circumstances.Before taking this drug, talk to your doctor about possible interactions if you are taking other medications, both prescription and over-the-counter.
  • Other Medical Problems: Report any other medical problems to your doctor before using this drug. If you have asthma, chronic lung disease, or emphysema, using this drug may cause serious breathing problems. Moreover, this drug may make depression, hyperactivity (in children), liver disease, or kidney disease worse. People with porphyria should not use this drug.

3 Proper Usage

To use Mysoline properly, you must follow all instructions given by your doctor. If you take more of this medicine, take it more often, or do not take it for how long your doctor has prescribed, chances of side effects may be increased. Primidone may be used along with other medicines for seizures. Take it regularly as prescribed by your doctor.


Follow your doctor’s orders when it comes to dosage. The following information is only for the average dosage of this drug. The number of doses, the number of hours between doses, and how long you will take this drug depend on your health condition, your progress, and how well you react to this medicine.

For prevention of seizures in adults, teens, and children 8 years old and up, the usual dose is 100-125 mg once a day before bed. The dose may be increased as per your doctor’s advice, with a maximum of 2000 mg a day. For children below 8 years old, the initial dose is usually 50 mg at bedtime, to be taken once a day.

Missed Dose

Take the missed dose as soon as possible. In case it is almost time for the next dose, skip the missed one and follow your regular dosing schedule. Never take double doses.


Keep the medicine in an airtight container at normal room temperature. Keep it away from direct light, heat, and moisture. Do not let it freeze. Keep the medicine out of children’s reach. Throw away any outdated medicine or medicine that are not in use. Keep the medicine in its original package until needed.

4 Precautions to Take

Before using Mysoline, there are some precautions you must take. While taking this medicine, regular visits to your doctor are necessary, to see if the drug is working properly or if there are any unwanted effects from using this medicine.

Use an effective form of birth control to avoid pregnancy, since using this drug while pregnant can be harmful to your unborn baby. If you have become pregnant while on treatment, inform your doctor right away.

If you are already taking this drug for several weeks, do not stop using it suddenly; check first with your doctor. Taking this drug may cause agitation, irritability, or display of abnormal behaviors. Some people experience becoming more depressed or having suicidal thoughts.

Call your doctor right away if you notice these side effects. This medicine may affect the results of certain medical tests. Before any medical tests, inform your attending doctor that you are taking this medicine. Furthermore, it is necessary to inform your attending physician or dentist that you are using this drug before any kind of treatment, surgery, or dental procedures.

Primidone may aggravate the effects of alcohol and CNS depressants, such as antihistamines, cold medicines, sedatives, tranquilizers, and prescription pain relievers. If you are taking any of these medicines, check with your doctor before using primidone.

You may feel dizzy, drowsy, less alert, or lightheaded when taking this drug. Be cautious when driving or operating machines, or avoid doing these activities while taking this drug. Birth control pills may not work properly, so to be on the safe side, it is best to use another form of birth control while taking this drug.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Mysoline.

Consult your doctor if any of these side effects occur:

  • Shakiness
  • Unsteady walk
  • Problems with muscle control, such as unsteadiness or trembling
  • Unusual excitement
  • Restlessness (especially in children and in the elderly)
  • Chills
  • Hoarseness
  • Fever
  • Fainting spells
  • Sore throat
  • General feeling of weakness
  • Lower back or side pain
  • Irregular heartbeat
  • Painful or difficult urination
  • Skin rash
  • Pale skin shortness of breath
  • Mouth sores
  • Unusual bleeding or bruising
  • Unusual weakness

Some of these side effects may occur without needing medical attention. These may go away as your body gets used to the medicine. However, in the case of symptoms of overdose, emergency medical attention is necessary.

These symptoms include:

  • Continuous, uncontrolled rolling eye movements
  • Confusion
  • Double vision
  • Troubled breathing