Asthma has an important genetic component but without a well-defined hereditary pat- tern, with heritability rates from 36 to 79%. In addition to risk to develop the disease, inheritance is implied to regulate its expression and severity. Asthma is a polygenic disease, multiple genes (more than 100) have been related to the expression of the disease in association with allergies, this in relation to the interaction these genes present with each other and with the environment. The most important environmental factors that condition an increase in the expression of these genetic alterations are: Fungal infections or exposure to proteases of some exoparasites (mites), exposure to allergens as well as irritant contaminants such as tobacco or suspended particles such as monoxide de carbon, other factors such as obesity, deficiency of immunoglobulins (type A), even the working environment can trigger allergic (allergic) or non-allergic asthma. The genotype or genetic structure that increases the risk of asthma is not modifiable, but the genes involved interact and generate a response to the risk factors commented on, so avoiding these decreases the possibility of suffering from the disease or even decreases the possibility of an earlier expression or of greater gravity, influencing positively in the symptoms control.
I hope to have resolved your doubt, greetings from Mexico.