“Psychiatry question about meds?”

There are antidepressants that are not sedating. Your best way of
evaluating these would be with your prescribing doctor.

Hello, the answer to your question is that what is a good substitute depends on your diagnosis (why you are on the meds), what other meds have and have not worked for you in the past, which side effects would be least problematic, and also on how much work you are willing to invest in improving your lifestyle. Having said that, there may be some general things to say about newer meds to replace clomipramine for the treatment of OCD or Depression. All of the SSRIs work for both diagnoses, though some are FDA approved for one or the other diagnosis. Prozac is the least sedating, and some would even call it mildly activating of the SSRI category. There are also the newer multimodal agents such as Trintellix and Viibryd which are only approved for depression and have fewer sexual side effects, less sedation, and no weight gain. However, they are pricy, and you have to check your individual plan to see whether they are covered. They only have an indication for depression, but not OCD. As far as the Seroquel, what could be used to replace it varies greatly on why you need it in the first place. For example, if you were using Seroquel as an adjunctive treatment for OCD or it would be a different story than if you were using it to treat depression, which would also be different if you were using it to treat insomnia. As an adjunct for depression, you may consider Wellbutrin. For OCD, you may consider a less sedating atypical such as Geodon. For Bipolar, you may want to consider a less sedating atypical such as Vraylar which also has an FDA indication for Bipolar, while if you were taking the Seroquel for sleep, you may want to try some natural supplements such as Melatonin 1 mg and Magnesium L-threonate 500 mg ninety minutes before bedtime. In short, you should really get a second opinion if your doctor is not willing to work with you on finding some alternatives that have less of an impact on your lifestyle.

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