Internist Questions Internist

Vaccine?

Is it safe to get a COVID vaccine if I have the homozygous MTHFR mutation?

Female | 28 years old

2 Answers

There is a clear trend toward the worldwide prevalence of *MTHFR* 677 and COVID‐19 incidence and mortality. Published data exist documenting this observation that disease from COVID may be more severe. HOWEVER, the vaccine is not considered unsafe or contraindicated with MTHFR. The vaccine is considered helpful to prevent COVID in you. Long ago, the polio vaccine was questioned as unsafe, but the actual data with review did not contraindicate any vaccine in the setting of MTHFR -- most importantly, be sure your intake of B vitamins is sufficient and daily and that your intake of FOLIC acid is daily.

Rex
I would just avoid J&J vaccine