Dr. Karl Deisseroth MD

Publications

• tureStructural and molecular interrogation of intact biological systems.2013
• TUREDiverging neural pathways assemble a behavioural state from separable features in anxiety2013
• TUREDopamine neurons modulate neural encoding and expression of depression-related behaviour2013
• TUREA prefrontal cortex-brainstem neurol projection that controls response to behavioural challenge2012
• TURECrystal structure of the channelrhodopsin light-gated cation channel2012
• CELLThe Microbial Opsin Family of Optogenetic Tools2011
• TURENeocortical excitation/inhibition balance in information processing and social dysfunction2011
• NEURONOptogenetics in Neural Systems2011
• TUREAmygdala circuitry mediating reversible and bidirectiol control of anxiety2011
• TURE METHODSOptogenetics2011
• ANNUAL REVIEW OF NEUROSCIENCE, VOL 34The Development and Application of Optogenetics2011
• SCIENCECholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning2010
• TUREParvalbumin neurons and gamma rhythms enhance cortical circuit performance2009
• TUREDriving fast-spiking cells induces gamma rhythm and controls sensory responses2009
• SCIENCEPhasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning2009
• TURETemporally precise in vivo control of intracellular siglling2009
• SCIENCEOptical Deconstruction of Parkinsonian Neural Circuitry2009
• ture methodsCLARITY for mapping the nervous system.2013
• JOURL OF NEUROSCIENCEHypothalamic Neurotensin Projections Promote Reward by Enhancing Glutamate Transmission in the VTA2013
• jourl of neuroscienceMultiple Sources of Striatal Inhibition Are Differentially Affected2013
• PLOS ONEOptogenetic Delay of Status Epilepticus Onset in an In Vivo Rodent Epilepsy Model2013
• NEURONMaking Waves: Initiation and Propagation of Corticothalamic Ca2+ Waves In Vivo2013
• NeuronMaking waves: initiation and propagation of corticothalamic Ca2+ waves in vivo.2013
• SCIENCEThe Brain Activity Map2013
• ScienceNeuroscience. The brain activity map.2013
• ACS NOnotools for Neuroscience and Brain Activity Mapping2013
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMPosttraining optogenetic manipulations of b2013
• TURERapid regulation of depression-related behaviours by control of midbrain dopamine neurons2013
• JOURL OF NEUROSCIENCEGlutamatergic Neurotransmission between the C1 Neurons2013
• JOURL OF NEUROSCIENCEOptogenetic Inhibition of Dorsal Medial Prefrontal Cortex Attenuates Stress2013
• TURE NEUROSCIENCEClosed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical2013
• Science.Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior.2013
• Neuron.A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote0
• ture Neuroscience. Advance Online PulbicationA causal link between prediction errors, dopamine neurons and learning0
• Neuron.Engineering approaches to illumiting brain structure and dymics.0
• PS.Causal interactions between fronto-parietal central executive and default-mode networks in humans.0
• PS.Optogenetics.0
• Trends in Cognitive Sciences.Light microscopy mapping of connections in the intact brain.0
• Optogenetics.Optogenetics in the behaving rat: integration of diverse new technologies in a vital animal model.0
• Neuron.Optogenetic activation of an inhibitory network enhances feedforward functiol connectivity0
• ADDICTION BIOLOGYOptogenetic inhibition of cocaine seeking in rats2013
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMPrefrontal D1 dopamine sigling is required for temporal control2012
• TURE METHODSTwo-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation2012
• TURE METHODSTwo-photon optogenetics of dendritic spines and neural circuits2012
• SCIENCE TRANSLATIOL MEDICINEOptogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy2012
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMReversible online control of habitual behavior by optogenetic perturbation of medial prefrontal2012
• TUREInput-specific control of reward and aversion in the ventral tegmental area2012
• JOURL OF NEUROSCIENCEHigh-Frequency Hippocampal Oscillations Activated by Optogenetic Stimulation of Transplanted Human2012
• JOURL OF BIOLOGICAL CHEMISTRYColor-tuned Channelrhodopsins for Multiwavelength Optogenetics2012
• TURENeurol circuitry mechanism regulating adult quiescent neural stem-cell fate decision2012
• ACS NOPhotothermal Genetic Engineering2012
• TUREActivation of specific interneurons improves V1 feature selectivity and visual perception2012
• TURE NEUROSCIENCEWhen the electricity (and the lights) go out: transient changes in excitability2012
• CELL REPORTSExpanding the Repertoire of Optogenetically Targeted Cells with an Enhanced Gene Expression System2012
• NEURONStriatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons2012
• EUROPEAN JOURL OF NEUROSCIENCEAltered profile of basket cell afferent sypses in hyper2012
• BIOLOGICAL PSYCHIATRYOptogenetics and Psychiatry: Applications, Challenges, and Opportunities2012
• MOLECULAR PSYCHIATRYA critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction2012
• TUREOptogenetic stimulation of a hippocampal engram activates fear memory recall2012
• JOURL OF NEUROSCIENCESyptic Activity Unmasks Dopamine D2 Receptor Modulation of a Specific Class of Layer V Pyramidal2012
• TURE REVIEWS NEUROSCIENCEOptogenetic investigation of neural circuits underlying brain disease in animal models2012
• NEURONGABA Neurons of the VTA Drive Conditioned Place Aversion2012
• JOURL OF BIOLOGICAL CHEMISTRYStructural Model of Channelrhodopsin2012
• JOURL OF NEURAL ENGINEERINGIntegrated device for combined optical neuromodulation2012
• ture methodsPrinciples for applying optogenetic tools derived from direct comparative alysis of microbial2012
• ture neuroscienceOptetrode: a multichannel readout for optogenetic control in freely moving mice.2012
• ture neuroscienceGABAergic circuits mediate the reinforcement-related sigls of striatal cholinergic interneurons.2012
• TURE NEUROSCIENCEGABAergic circuits mediate the reinforcement-related sigls of striatal cholinergic interneurons2012
• TURE NEUROSCIENCEOptetrode: a multichannel readout for optogenetic control in freely moving mice2012
• Mol Psychiatry.A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction2012
• NEURONRecombise-Driver Rat Lines: Tools, Techniques2011
• TURE NEUROSCIENCELeptin regulates the reward value of nutrient2011
• TURENeurol filtering of multiplexed odour representations2011
• PLOS ONESNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate alpha-Synuclein2011
• TURE NEUROSCIENCEHemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity2011
• CELLDymics of Retrieval Strategies for Remote Memories2011
• JOURL OF NEUROSCIENCEDifferential Modulation of Excitatory and Inhibitory Striatal Syptic Transmission by Histamine2011
• CURRENT BIOLOGYIn Vivo Optogenetic Stimulation of Neocortical Excitatory Neurons Drives Brain-State2011
• BIOPHYSICAL JOURLMultiscale Computatiol Models for Optogenetic Control of Cardiac Function2011
• TURE METHODSCell type-specific channelrhodopsin2011
• TURE NEUROSCIENCEA new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy2011
• JOURL OF NEUROSCIENCEOptogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward2011
• TUREExcitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking2011
• NEUROSURGERYOPTOGENETICS: BACKGROUND AND CONCEPTS FOR NEUROSURGERY2011
• IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERINGChallenges and Opportunities for Next-Generation Intracortically Based Neural Prostheses2011
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMHigh-efficiency channelrhodopsins for fast neurol stimulation at low light levels2011
• PLOS ONEFunctiol Integration of Grafted Neural Stem Cell2011
• TURE NEUROSCIENCEAn optogenetic toolbox designed for primates2011
• JOURL OF NEUROSCIENCEActive Expiration Induced by Excitation of Ventral Medulla in Adult Anesthetized Rats2011
• IEEE JOURL OF SOLID-STATE CIRCUITSAn Implantable Optical Stimulation Delivery System for Actuating an Excitable Biosubstrate2011
• STEM CELLSTracking Stem Cell Differentiation in the Setting of Automated Optogenetic Stimulation2011
• t Methods.Optogenetics.2011
• ture.Amygdala circuitry mediating reversible and bidirectiol control of anxiety.2011
• A, B., P, S., J, M., KM, T., K, D., P, H.High-efficiency channelrhodopsins for fast neurol stimulation at low light levels.0
• PLOS ONEDrug-Driven AMPA Receptor Redistribution Mimicked by Selective Dopamine Neuron Stimulation2010
• TURE NEUROSCIENCETuning arousal with optogenetic modulation of locus coeruleus neurons2010
• JOURL OF NEUROSCIENCEAntidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex2010
• TUREEncoding of conditioned fear in central amygdala inhibitory circuits2010
• TUREGenetic dissection of an amygdala microcircuit that gates conditioned fear2010
• STEM CELLSFunctiol Control of Transplantable Human ESC-Derived Neurons via Optogenetic Targeting2010
• SCIENCECell Type-Specific Loss of BDNF Sigling Mimics Optogenetic Control of Cocaine Reward2010
• TURE MEDICINEOrderly recruitment of motor units under optical control in vivo2010
• SCIENCEAstrocytes Control Breathing Through pH-Dependent Release of ATP2010
• TURERegulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry2010
• SCIENCEGenetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa2010
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMOptical activation of lateral amygdala pyramidal cells instructs associative fear learning2010
• TUREGlobal and local fMRI sigls driven by neurons defined optogenetically by type and wiring2010
• JOURL OF NEUROSCIENCEGlutamatergic Sigling by Mesolimbic Dopamine Neurons in the Nucleus Accumbens2010
• JOURL OF NEUROSCIENCEDlx5 and Dlx6 Regulate the Development of Parvalbumin-Expressing Cortical Interneurons2010
• CELLMolecular and Cellular Approaches for Diversifying and Extending Optogenetics2010
• TURE NEUROSCIENCEUltrafast optogenetic control2010
• t Med.Orderly recruitment of motor units under optical control in vivo.2010
• TURE PROTOCOLSTargeted optogenetic stimulation2010
• TURE PROTOCOLSOptogenetic interrogation of neural circuits: technology for probing mammalian brain structures2010
• Sci Am.Controlling the brain with light2010
• JP, J., H, H., MH, M., R, B., K, D., HT, B.Optical activation of lateral amygdala pyramidal cells instructs associative fear leaJohansen JP0
• J Neural Eng.Special issue on optical neural engineering: advances in optical stimulation technology.2010
• FRONTIERS IN NEURAL CIRCUITSOptogenetic dissection of neurol circuits in zebrafish using viral gene transfer and the Tet system2009
• JOURL OF NEURAL ENGINEERINGIntegrated device for optical stimulation2009
• JOURL OF NEUROSCIENCESleep Homeostasis Modulates Hypocretin-Mediated Sleep-to-Wake Transitions2009
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMOptogenetic control of epileptiform activity2009
• EMBO MOLECULAR MEDICINEInduced chromosome deletions cause hypersociability2009
• TURE NEUROSCIENCEBi-stable neural state switches2009
• CURRENT BIOLOGYEscape behavior elicited by single2008
• BRAIN CELL BIOLOGYeNpHR: a tronomos halorhodopsin enhanced for optogenetic applications2008
• BRAIN CELL BIOLOGYImproved expression of halorhodopsin for light-induced silencing of neurol activity2008
• AMERICAN JOURL OF PSYCHIATRYBrain circuit dymics2008
• TURE NEUROSCIENCERed-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri2008
• AMERICAN JOURL OF PSYCHIATRYControlling neurol activity2008
• t Neurosci.Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri.2008
• Am J Psychiatry.Brain circuit dymics2008
• JOURL OF NEUROSCIENCETargeting and readout strategies for fast optical neural control in vitro and in vivo2007
• CURRENT BIOLOGYNociceptive neurons protect Drosophila larvae from parasitoid wasps2007
• TURENeural substrates of awakening probed with optogenetic control of hypocretin neurons2007
• Integratio0

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