1 What is Mefoxin?

Brand: Mefoxin

Generic: Cefoxitin

Mefoxin injection is used to treat bacterial infections in many different parts of the body. This medicine is also given before certain types of surgery to prevent infections.

Mefoxin injection belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Powder for Solution
  • Solution

2 What to Know Before Using

Your doctor will inform you of what you need to know before using Mefoxin. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.

For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric Population:

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of cefoxitin injection in children. However, safety and efficacy have not been established in children younger than 3 months old.

Geriatric Population:

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cefoxitin injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving cefoxitin injection.


All Trimesters: Category B: Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.


Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions:

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions:

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems:

The presence of other medical problems may affect the use of this medicine.

Make sure you tell your doctor if you have any other medical problems, especially:

  • Colitis (inflammation in gut), history of 
  • Diarrhea, severe, history of 
  • Seizures—Use with caution. May make these conditions worse
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body

3 Proper Usage

To use Mefoxin properly, you must follow all instructions given by your doctor. A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.

4 Precautions To Take

In using Mefoxin, you must be careful and take some precautions as advised by your doctor. If your symptoms or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Cefoxitin injection may cause diarrhea, and in some cases, it can be severe. Do not take any medicine or give medicine to your child to treat diarrhea without first checking with your doctor.

Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Before you or your child have any medical tests, tell the medical doctor in charge that you are receiving this medicine. The results of some tests may be affected by this medicine.

5 Potential Side Effects

If you notice any side effects of Mefoxin, immediately make an appointment with your doctor. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common:

  • Changes in skin color
  • Pain
  • Swelling of the foot or leg
  • Tenderness


  • Agitation
  • Coma
  • Confusion
  • Decreased urine output
  • Depression
  • Dizziness
  • Headache
  • Hostility
  • Irritability
  • Lethargy
  • Muscle twitching
  • Nausea
  • Rapid weight gain
  • Seizures
  • Stupor
  • Swelling of the face, ankles, or hands
  • Unusual tiredness or weakness

Incidence not known:

  • Abdominal or stomach cramps or tenderness
  • Back, leg, or stomach pains
  • Bleeding and bruising
  • Bleeding gums
  • Blistering, peeling or loosening of the skin
  • Bloating
  • Bloody or cloudy urine
  • Bloody, black, or tarry stools
  • Chest pain
  • Chills
  • Clay-colored stools
  • Cloudy urine
  • Cough
  • Coughing up blood
  • Cracks in the skin
  • Dark urine
  • Decrease in urine output or decrease in urine-concentrating ability
  • Diarrhea
  • Diarrhea, watery and severe, which may also be bloody
  • Difficult or labored breathing
  • Difficult or painful urination
  • Difficulty with breathing, chewing, swallowing, or talking
  • Dizziness
  • Double vision
  • Drooping eyelids
  • Fast heartbeat
  • Feeling of discomfort
  • Fever
  • General body swelling
  • Greatly decreased frequency of urination or amount of urine
  • Headache
  • High fever
  • Hives
  • Increased menstrual flow or vaginal bleeding
  • Increased thirst
  • Inflammation of the joints
  • Itching
  • Itching of the vagina or genital area
  • Joint or muscle pain
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • Loss of appetite
  • Loss of heat from the body
  • Muscle aches
  • Muscle weakness
  • Nosebleeds
  • Pain during sexual intercourse
  • Pale skin
  • Paralysis
  • Prolonged bleeding from cuts
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Rash
  • Red or black, tarry stools
  • Red or dark brown urine
  • Red skin lesions, often with a purple center
  • Red, irritated eyes
  • Red, swollen skin
  • Scaly skin
  • Severe tiredness
  • Shortness of breath
  • Sore throat
  • Sores, ulcers, or white spots on the lips or in the mouth
  • Sudden decrease in the amount of urine
  • Swelling of the feet or lower legs
  • Swollen lymph glands
  • Swollen or painful glands
  • Thick, white vaginal discharge with no odor or with a mild odor
  • Tightness in the chest
  • Troubled breathing with exertion
  • Unexplained bleeding or bruising
  • Unpleasant breath odor
  • Unusual bleeding or bruising
  • Unusual weight loss
  • Vomiting
  • Vomiting of blood
  • Wheezing
  • Yellowing of the eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common:

  • Red streaks on the skin
  • Swelling, tenderness, or pain at the injection site

Incidence not known:

  • Hives or welts
  • Redness of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.