Good question. No, it doesn't mean that you will never develop diabetes. The Diabetes Prevention Program studied several thousand prediabetic patients for several years breaking them down into two groups; one which was placed on Metformin 850 twice a day and other on diet with goal to lose 7% of their body weight along with exercise, combination of both called lifestyle changes. These two groups were compared to a prediabetic group receiving no care or placebo meds. The diet and exercise group demonstrated an over 50 percent reduction in the development of diabetes and in those who did develop the disease a delay by several years. The metformin group also showed a decrease in the number of people who developed diabetes by 30 percent with a similar delay in onset in those who went on to develop the disease. However, type 2 diabetes is a progressive disease involving both beta cell dysfunction (insulin producing cells) and insulin tissue resistance and this progressive nature was shown in further studies when the metformin was stopped.with the development of diabetes.
Your take home message is to diet, exercise and take metformin to delay the development of diabetes.
Marvin A. Leder, MD, FACP, FACE