Plaque buildup is a function of biological processes which we don't need to detail, but is essentially the accretion of your salivary fluids, certain bacteria, certain biochemical elements of your body, and food particle retention. These groups combine to form plaque buildup over time, sort of in an "incubator" type of fashion. As you see in nature, all living things "incubate" (read "form) at a different rate. Some people get plaque buildup immediately after their dental cleaning, while some people get plaque buildup after weeks have gone by. To answer your question directly: The best defense is a good offense, or so goes the saying. Offensively minded, you can opt to brush and floss more than the average bear, so to speak. Not a frequent flosser? Floss more. An average brusher? Brush more. Professionally, you can opt to go to your dental hygienist more than twice a year. Be forewarned, however, that dental insurances only pay for cleanings twice a year at best. Your 3rd, 4th, and more dental cleanings will have be paid for "out of pocket". A tip here: for those extra dental cleanings: ask your dental professional for ONLY a dental cleaning. NO exam, NO x-rays on those 3rd, 4th, or 5th cleanings. That should significantly lower your out-of-pocket expenses. Your dentist will be happy to have his hygienist's chair time filled and her payroll covered, and you'll save $$$ on those extra cleaning appointments. Like I said however, be more aggressive at home to lower plaque buildup between dental visits.