Pathologist Questions Blood Tests

What blood tests can diagnose celiac disease?

My doctor thinks that I have celiac disease, so along with a biopsy, he would also like me to have a blood test to help confirm it. What blood tests diagnose celiac disease?

2 Answers

Ordering a serologic test to check for antibodies is usually the first step. The serologic test will check for IgA antibodies, specifically tTG-IgA will be positive in 93% of cases with Celiac disease who are on a gluten-containing diet. Also, genetic testing for human leukocyte antigens (HLA-DQ2 and HLA-DQ8) can be used to rule out Celiac disease. Thank you.
The ones I am familiar with are IgA and tissue transaminase. It is best to do tissue and serology correlation. Each one by themselves could be due to other things.
Good luck.

RB Thomas, MD