1 What is Akynzeo?

Brand: Akynzeo

Generic: Netupitant and Palonosetron

Akynzeo is used to prevent nausea and vomiting caused by cancer medications (chemotherapy).

Palonosetron and Netiputant work by blocking the signals to the brain that cause nausea and vomiting.

This medication is only available with your doctor’s prescription.

This product is available in the following form:

  • Capsule

2 What To Know Before Using

As with all medicines, the risks of using Akynzeo must be compared to how much this medication will help you. This is a decision that you and your doctor will make together.

For this medication, there are many things that need to be considered:

  • AllergiesInform your doctor if you have ever had an allergic reaction to Doxorubicin or to any other medications. It is also important to inform your doctor of any non-medicine allergies such as foods, dyes, preservatives or animals.
  • Pediatric: No appropriate studies have been performed on the relationship of age to the effects of this medication in children. Safety and efficacy have not been established.
  • Geriatric: Up-to-date studies have not shown any problems specific to the elderly that would limit the use of this medication in the elderly population.
  • Pregnancy: This medication is listed as Pregnancy Category C. This means that animal studies have shown an adverse effect and no studies have been performed on pregnant women OR there are no adequate studies on pregnant animals and pregnant women.
  • Breastfeeding: There are no up-to-date studies in women for determining infant risk when using this medication while breastfeeding. Weigh the potential risks with the benefits before taking this medication while breastfeeding.
  • Drug Interactions: Certain medications should not be used together. However, in certain cases, two medications may be used together, even if an interaction might occur. In these cases, your doctor may want to change your dose or take other precautions.When taking this medication, it is important that you inform your doctor if you are taking any of the medications listed below. The following interactions were selected on the basis of potential significance and are not all-inclusive.Using this medication with any of the following is not recommended. Your doctor may decide not to treat you with this medication, or change some of the other medications you take:
    • ApomorphineUsing this medication with any of the following medication is not recommended, but may be unavoidable in some cases. Your doctor may make the decision not to treat you with this medication or change some of the other medications you take:
    • Almotriptan
    • Amineptine
    • Amitriptyline
    • Amitriptylinoxide
    • Amoxapine
    • Brompheniramine
    • Buspirone
    • Carbamazepine
    • Chlorpheniramine
    • Cilostazol
    • Citalopram
    • Clomipramine
    • Cocaine
    • Cyclobenzaprine
    • Desipramine
    • Desvenlafaxine
    • Dextromethorphan
    • Dibenzepin
    • Domperidone
    • Donepezil
    • Doxepin
    • Duloxetine
    • Efavirenz
    • Eletriptan
    • Enzalutamide
    • Escitalopram
    • Fentanyl
    • Fluoxetine
    • Fluvoxamine
    • Fosphenytoin
    • Frovatriptan
    • Furazolidone
    • Hydroxytryptophan
    • Imipramine
    • Iproniazid
    • Isocarboxazid
    • Levomilnacipran
    • Linezolid
    • Lithium
    • Lofepramine
    • Lorcaserin
    • Melitracen
    • Meperidine
    • Methadone
    • Methylene Blue
    • Milnacipran
    • Mirtazapine
    • Mitotane
    • Moclobemide
    • Naloxegol
    • Naratriptan
    • Nefazodone
    • Nialamide
    • Nilotinib
    • Nortriptyline
    • Olaparib
    • Opipramol
    • Oxcarbazepine
    • Paroxetine
    • Pentazocine
    • Phenelzine
    • Phenobarbital
    • Phenytoin
    • Piperaquine
    • Primidone
    • Procarbazine
    • Protriptyline
    • Rasagiline
    • Rifabutin
    • Rifampin
    • Rifapentine
    • Rizatriptan
    • Selegiline
    • Sertraline
    • Sibutramine
    • Simeprevir
    • St John's Wort
    • Sumatriptan
    • Tapentadol
    • Tianeptine
    • Tramadol
    • Tranylcypromine
    • Trazodone
    • Trimipramine
    • Tryptophan
    • Venlafaxine
    • Vilazodone
    • Vortioxetine
    • ZolmitriptanUsing this medication with any of the following medications may increase your risk of side effects. However, using both medications may be the best treatment for you. If both medications are prescribed together, your doctor may change the dose or how often you take one or both medications:
    • Dexamethasone
  • Other Interactions: Certain medications should not be used while eating, or while eating certain foods in case of negative interactions. Using alcohol or tobacco with certain medications may also cause negative interactions. Talk with your doctor about the use of your medication with food, alcohol or tobacco.

3 Proper Usage

Only take Akynzeo as directed by your doctor. Do not take more, less or for a longer or shorter period of time than your doctor tells you.

This medication comes with a patient information brochure. It is very important that your read this information. Ask your doctor if you have any questions.


Different patients will be given a different dose of this medication based on the strength of the medication. The number of doses you take each day, the time between doses and the length of time you take this medication depends on the reason you are taking this medication.

The following information only includes the average dose of this  medication. If your dose is different, do not change it without first speaking to your doctor.

  • Adullts - 1 capsule given within 1 hour before starting cancer treatment
  • Children - Use and dose must be determined by your doctor

Missed Dose

If you miss a dose of this medication, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and resume your normal dosing schedule. Do not double dose.


Store this medication in a closed container at room temperature. Keep it away form heat, moisture and direct light. Do not freeze. Keep out of the reach of children.

Do not keep expired medication or medication you no longer need. Ask your doctor how to dispose of any medication you do not use.

4 Precautions To Take

Akynzeo may cause Anaphylaxis, which is life-threatening and requires immediate medical attention.

Inform your doctor immediately if you have a rash, fast heartbeat (tachycardia), fever, hives, itching, irritation, hoarseness, joint pain, stiffness or swelling, redness of the skin, swelling of the eyelids, face, lips, hands or feet, chest tightness, trouble breathing or trouble swallowing after using this medication.

This medication may cause a serious condition called Serotonin syndrome if taken together with some medications such as Fentanyl, Lithium, an MAO inhibitor, medication to treat migraines or medications to treat depression.

Do not take other prescriptions or over-the-counter medications without asking your doctor.

5 Potential Side Effects

Akynzeo may produce unwanted affects along with the intended effects. Although not all of these side-effects may occur, if they do occur they may need medical attention.

Some side effects that may occur do not normally need medical attention. These may leave as your body becomes accustomed to treatment. Ask your doctor about ways to prevent or reduce some of these side effects.

Talk to your doctor if any of the following side effects continue or are bothersome, or if you have questions:

More Common

Less Common

Some patients may experience other side effects that are not listed. Check with your doctor if you notice any other side effects.

Ask your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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