1 What is Covaryx?

Brand: Covaryx, Covaryx HS, Essian, Estratest, Menogen, Syntest DS, and Syntest HS

Generic: Esterified estrogens and methyltestosterone

Brand name: 

Covaryx, Covaryx HS, Essian, Estratest, Menogen, Syntest DS, and Syntest HS

Estrogen and Androgen are hormones that are normally produced by the ovaries and adrenal glands, respectively. Estrogen, however, is more abundant in females while androgen is found in greater amounts in males. Estrogen is responsible for the normal development of the reproductive system in females. It also regulates the menstrual cycle. The combination of Estrogen and Androgen is usually used in the treatment of menopausal symptoms which include unusual sweating, hot flashes, chills, faintness, and dizziness.

The manifestations of these symptoms are brought about by the decline of estrogen and androgen in menopausal women. Your physician can also use this combination to treat other medical conditions.

It should be noted though that there has been enough evidence to prove the claim that estrogen can keep patients feeling young or relieve emotional symptoms.

Estrogen and androgen combination is usually sold in tablet form and can only be purchased with a prescription.

Have a question aboutEstrogen Replacement Therapy?Ask a doctor now

2 What to Know Before Using

This medication usually comes with a patient information sheet. You should read that one carefully. Prior to starting treatment, however, you and your physician must discuss the risks and benefits associated with treatment. There are many considerations to take note of as well.

Inform your doctor or healthcare team if you are allergic to medicines of the same kind. Also, you need to disclose information regarding allergies to food, dyes, preservatives, and/or animals.

Studies have shown that the Estrogen and Androgen combination does not cause any harmful side effects in geriatric patients. The same goes for use in younger women. Taking certain Estrogen and Androgen medications during pregnancy can cause harm to the unborn child. Therefore, using this combination is not recommended for pregnant women. It has also been found that Estrogen passes through breast milk but the effects on the baby are unknown.

Androgen, however, has not been found to be present in breast milk but can cause early sexual development in male children and masculine changes in female children. Nursing mothers should not take this medication. Estrogen and androgen combination interacts with other drugs as well. That’s why it’s important to inform your physician about any other medication you are taking. This combination should not be used together with Tranexamic acid.

On the other hand, concomitant treatment with:

  • Anisindione
  • Bupropion
  • Darunavir
  • Dasabuvir
  • Donepezil
  • Eliglustat
  • and Theophylline is not recommended but may be necessary at times.

There are also foods you need to avoid when taking this combination. You can talk to a healthcare professional about this. The Estrogen and Androgen combination can also worsen pre-existing medical conditions.

Use of this medication is not recommended for women with:

3 Proper Usage

Dosage and timing is different for every individual. It is essential that you follow your physician’s instructions regarding when and how many times to take it. It is advisable to drink it at a particular time each day. This can decrease the risk of experiencing side effects.

You may feel nausea for the first few days but this feeling usually goes away on its own. However, if it becomes worse or bothersome, you can try taking the medication with food or after eating.

The dosage will depend on what time of combination you are taking and your condition as determined by your doctor. If you forget a dose, take it immediately. However, skip it all together if the next timing is near.

Store your medications in a safe and sealed container.

Do not freeze it.

Discard any expired medication.

4 Precautions To Take

Go to your checkups diligently, so that your physician can check your progress and make sure there are no unwanted side effects. Normally, checkups can be every 6 or 12 months. However, some doctors might need to check you more often depending on your condition.

It has been speculated that taking Estrogen can put women at risk of developing breast cancer although no conclusive evidence has been found. However, you should do regular self-checks and a get a mammogram done if suggested by your doctor. Use a toothbrush with soft bristles and floss carefully because this medication can also cause gum bleeding in some women.

For diabetic patients, monitor your blood sugar levels regularly since Estrogen and Androgen combination can decrease blood sugar. Smoking while using estrogen-containing contraceptives can put you at a higher risk of developing blood clots and other cardiovascular problems.

This medication should not be shared with someone else since it was particularly prescribed for you by your physician.

5 Potential Side Effects

Aside from precautions, you also need to discuss with your doctor the possible side effects of this medication. In rare cases, long-term use of Estrogen and Androgen combination has caused liver cancer, tumors, and peliosis hepatis. The risk of developing Endometrial cancer can also increase with prolonged use.

The Androgen in the medication can also cause masculine changes in women like deepening of the voice and unnatural hair growth. Call your physician right away of you experience:

Side effects that may not require medical attention include abdominal bloating, stomach cramps, temporary loss of appetite, mild nausea, and/or vomiting. You may experience other side effects.

Notify your doctor if any of the symptoms become worse or do not improve.

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