Generic: Estradiol Gel
Divigel is a gel used in treating moderate to severe vasomotor symptoms associated with menopause. This drug is available as a gel containing estradiol 0.25 milligram in 0.25 gram, estradiol 0.5 milligram in 0.5 gram or estradiol 1 milligram in 1 gram.
You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.
Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also use this drug at the same time each day.
This drug is to be applied to the skin only. Avoid using it in the face, groin, or underarms, or for diaper rash, unless told so by your doctor. Divigel is often used on the upper thigh area as directed by your doctor, usually once daily.
First, wash and dry your hand before applying. The area should be cleansed and dried. The medication should be applied as a thin film to be gently rubbed in, as instructed by your doctor. Avoid covering or wrapping the treated area. Wash your hands after use. Avoid contact with eyes, mouth or mucous membranes. If contact occurs, rinse with plenty of water.
If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.
Divigel may interact with medications such as aromatase inhibitors (such as anastrozole, exemestane, letrozole), fulvestrant, raloxifene, tamoxifen and toremifene.)
There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.
Watch out for signs of allergic reactions such as:
Before taking this medication, tell your doctor or pharmacist if you have the following:
- Allergy to estradiol
- Vaginal bleeding of unknown cause
- Certain cancers (such as breast cancer, cancer of the uterus or ovaries)
- Blood clots
- Heart disease (such as heart attack)
- Liver disease
- Kidney disease
- Family medical history (especially breast lumps, cancer, blood clots, angioedema)
- Blood clotting disorders (such as protein C or protein S deficiency)
- High blood pressure
- High cholesterol or triglyceride levels
- Underactive thyroid (hypothyroidism)
- Mineral imbalance (low or high level of calcium in the blood)
- A certain hormone problem (hypoparathyroidism)
- Uterus problems (such as fibroids, endometriosis)
- Gallbladder disease
- Migraine headaches
- Mental/mood disorders (such as dementia, depression)
- A certain blood disorder (porphyria)