Relpax

1 What is Relpax?

Brand: Relpax

Generic: Eletriptan

Relpax is used to treat acute migraine headaches in adults. It may not be used for preventing migraine headaches and is not used for cluster headaches.

Relpax targets the brain in relieving the pain caused by a migraine headache. It is classified as trips. Many of the headaches are completely cleared after using eletriptan, others find that a headache becomes less painful and will be able t go back to their normal activities even when their headache is not completely cleared.

It has also been shown that it also clears other symptoms which may occur as a result of a migraine headache such as Nausea, vomiting, sensitivity to light, and sensitivity to sound.

Eletriptan is not an ordinary pain reliever. It does not relieve any kind of pain other than migraine headaches. This medicine is usually used for people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers.

Eletriptan may cause serious side effects in some people that have conditions such as heart or blood vessel disease. Ensure that you discuss with your doctor the risks of using this medicine as well as the benefits that it can do. This medicine is available only with your doctor's prescription.

2 What to Know Before Using

If you are about to start Relpax, speak with your doctor about what you need to know. Before making the decision to use this medicine, the risks of taking the medicine must be weighed against the good it will do.

This is a decision that both you and your doctor will make. For this medicine, the following needs to be done. Inform your medical doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.

Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric appropriate studies have not been performed on the relationship of age to the effects of eletriptan in the pediatric population. Safety and efficacy have not been established.

Moreover, geriatric appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of eletriptan in the elderly. However, elderly patients are more likely to have high blood pressure and age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving eletriptan.

Pregnancy animal studies have shown an adverse effect and there are no adequate studies in pregnant women or no animal studies have been conducted and there are no adequate studies in pregnant women.

Similarly, there are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions may occur when combining this medicine with other medicines and therefore, they should not be used together at all, in other cases, two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose or other precautions may be necessary.

When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended.

Your doctor may decide not to treat you with this medication or change some of the other medicines you take. They include:

  • Almotriptan
  • Amprenavir
  • Atazanavir
  • Boceprevir
  • Bromocriptine
  • Clarithromycin
  • Conivaptan
  • Delavirdine
  • Dihydroergotamine
  • Ergonovine
  • Ergotamine
  • Fosamprenavir
  • Frovatriptan
  • Imatinib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Linezolid
  • Lomitapide
  • Methylergonovine
  • Methysergide
  • Miconazole
  • Mifepristone
  • Naratriptan
  • Nefazodone
  • Nelfinavir
  • Posaconazole
  • Regorafenib
  • Ritonavir
  • Rizatriptan
  • Saquinavir
  • Sumatriptan
  • Telaprevir
  • Telithromycin
  • Ticagrelor
  • Tipranavir
  • Troleandomycin
  • Zolmitriptan

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. They include:

  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Ceritinib
  • Citalopram
  • Cobicistat
  • Crizotinib
  • Dabrafenib
  • Desvenlafaxine
  • Dolasetron
  • Duloxetine
  • Escitalopram
  • Fentanyl
  • Fluoxetine
  • Fluvoxamine
  • Granisetron
  • Hydroxytryptophan
  • Idelalisib
  • Levomilnacipran
  • Lorcaserin
  • Lumacaftor
  • Meperidine
  • Milnacipran
  • Mirtazapine
  • Nilotinib
  • Palonosetron
  • Paroxetine
  • Piperaquine
  • Reboxetine
  • Safinamide
  • Sertraline
  • Sibutramine
  • St John's Wort
  • Tapentadol
  • Tramadol
  • Trazodone
  • Venlafaxine
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Ziprasidone

It is also possible that certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur.

The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases.

If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco such as:

  • Grapefruit juice

The presence of other medical problems may affect the use of this medicine.

Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (chest pain) or Arrhythmia (heart rhythm problem) or a basilar migraine (a migraine with vision and hearing problems)
  • history of or Heart attack
  • history of or Heart or blood vessel problems or Hemiplegic a migraine (a migraine with some paralysis)
  • history of or Hypertension (high blood pressure)
  • uncontrolled or Ischemic bowel disease (bowels have a low blood supply) or Liver disease
  • severe or Peripheral vascular disease (clogged arteries) or Stroke
  • history of or Transient ischemic attack (TIA)
  • history of or Wolff-Parkinson-White Syndrome (heart rhythm problem)

This medicine is not recommended for use in people suffering from the following conditions: Coronary artery disease, family history of or diabetes or hypercholesterolemia (high cholesterol in the blood) or hypertension (high blood pressure) or obesity or Raynaud's syndrome. When using this medicine, use it with utmost caution since you may be at increased risk for certain side effects.

When used on people with heart conditions such as ventricular fibrillation, ventricular tachycardia. It must be used with caution. It is also known that using this medicine may make this conditions of Kidney or liver, even more, worse.

In people suffering from Kidney problems, Eletriptan may cause increased blood pressure in these patients while in people suffering from mild to moderate liver disease, it may cause the slower removal of the medicine from the body since they are metabolized in the liver and removed from the body by the kidney.

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3 Proper Usage

Proper usage of Relpax requires strict adherence to your doctor’s orders. Never take more of it, do not take it more often, and do not take it for a longer time than your doctor has instructed.

Using too much eletriptan may increase the chance of side effects. Do not use this medicine for a headache that is different from your usual migraines. Instead, check with your doctor.

To relieve your migraine as soon as possible, use this medicine as soon as the headache pain begins. Even if you get warning signals of a coming migraine (an aura), you should wait until the headache pain starts before using eletriptan.

Ask your doctor ahead of time about any other medicine you might take if eletriptan does not work. After you use the other medicine, check with your doctor as soon as possible. Headaches that are not relieved by eletriptan are sometimes caused by conditions that need other treatment.

If you feel much better after a dose of eletriptan, but your headache comes back or gets worse after a while, you may take one additional dose of this medicine 2 hours after the first dose. Do not use more than 80 milligrams in 24 hours.

Do not use this medicine for more than 3 headaches in any 30-day period, unless your doctor tells you to. This medicine comes with a patient information leaflet. It is very important that you read and understand this information.

Be sure to ask your doctor about anything you do not understand. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.

The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.

Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets for managing migraine headaches: Adults use 20 or 40 milligrams (mg) taken as a single dose.

If a migraine comes back after being relieved, another dose may be taken at least 2 hours after the first dose. Do not take more than 80 mg in any 24-hour period. In children, the use and dose must be determined by your medical doctor.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep it away from freezing. Keep out of reach of children. Do not keep outdated medicine or medicine that is no longer needed. Consult your healthcare professional how you should dispose of any medicine you do not use.

4 Precautions to Take

Before using Relpax, there are some precautions you must take. It is very important that your doctor checks your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Check with your doctor if you used this medicine and your migraine did not go away, or if your migraine got worse or started occurring more often.

This medicine may cause problems if you have heart disease. If your doctor thinks you might have a problem with this medicine, he or she may want you to take your first dose in the doctor’s office or clinic. This medicine may increase your risk of having abnormal heart rhythm, heart attack, angina, or stroke.

This is more likely to occur if you or a family member already has heart disease, if you have diabetes, high blood pressure, high cholesterol, if you smoke, if you are male and over 40 years of age, or if you are female and have gone through menopause.

Call your doctor right away if you have any symptoms of a heart problem, such as:

Call your doctor right away if you have any symptoms of a stroke, such as:

  • Confusion
  • Difficulty with speaking
  • Double vision
  • Headaches
  • An inability to move the arms, legs, or facial muscles
  • An inability to speak 
  • Slow speech

You should not take this medicine if you have used other triptan or ergot-type migraine medicines within the past 24 hours. Some examples of triptan medicines are:

Some examples of ergot-type medicines are:

Do not use this medicine if you have taken clarithromycin (Biaxin), itraconazole (Sporanox), ketoconazole (Nizoral), nefazodone (Serzone), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), or troleandomycin (Tao) in the past 72 hours.

Check with your doctor right away if you have chest discomfort, jaw or neck tightness after taking this medicine. Also, tell your doctor if you have sudden or severe abdominal or stomach pain or bloody diarrhea after using this medicine. Make sure your doctor knows about all the other medicines you are using.

Eletriptan may cause a serious condition called serotonin syndrome when taken with some medicines. This includes medicines to treat depression, such as:

Check with your doctor right away if you have agitation, confusion, diarrhea, excitement while talking that is not normal, fever, overactive reflexes, poor coordination, restlessness, shivering, sweating, trembling or shaking that you cannot control, or twitch. These could be symptoms of serotonin syndrome. This medicine may cause serious allergic reactions, including anaphylaxis.

Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Using eletriptan alone or in combination with other migraine medicines for 10 or more days per month may lead to worsening of a headache. You may keep a headache diary to record your headache frequency and drug use.

Check with your doctor right away if you have blurred vision, difficulty with reading, or any other change in vision while you are using this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). Some people feel drowsy or dizzy during or after a migraine, or after taking eletriptan to relieve a migraine.

As long as you are feeling drowsy or dizzy, do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

5 Potential Side Effects

Make sure you meet with your doctor in using Relpax to avoid unwanted potential side effects. All of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common:

  • Chest pain or tightness
  • Difficulty with swallowing
  • Tightness in the throat

Rare:

  • Chest discomfort
  • Dizziness
  • Headache
  • Nausea
  • Nosebleeds
  • Numbness or tingling in the face, arms or legs
  • Pain or discomfort in the arms, jaw, back or neck
  • Sweating
  • Vision problems
  • Vomiting

Incidence not known:

  • Abdominal or stomach pain
  • Agitation
  • Bloody diarrhea
  • Confusion
  • Cough
  • Diarrhea
  • Difficulty in speaking
  • Fainting
  • Fast, slow, pounding, or irregular heartbeat or pulse
  • Fever
  • Inability to move arms, legs, or facial muscles
  • Overactive reflexes
  • Pain in the arms legs, or lower back, especially pain in calves or heels upon exertion
  • Pale, bluish-colored, or cold hands or feet paleness or cold feeling in fingertips and toes
  • Poor coordination
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Restlessness
  • Seizures
  • A severe or a sudden headache
  • Shivering
  • Skin rash, hives, or itching
  • Slurred speech
  • Sudden loss of coordination
  • Sweating
  • Talking or acting with excitement you cannot control
  • Tingling or pain in the fingers or toes when exposed to cold
  • Trembling or shaking
  • Twitching
  • Unusual tiredness or weakness
  • Weak or absent pulses in the legs
  • Weakness in the arm or leg on one side of the body, sudden and severe

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common:

  • Lack or loss of strength sleepiness or unusual drowsiness

Less common:

  • Acid or sour stomach
  • Belching
  • Burning
  • Crawling
  • Itching
  • Numbness
  • Prickling, “pins and needles”, or tingling feelings
  • Dry mouth
  • Heartburn
  • Indigestion stomach
  • Soreness or discomfort stomach upset

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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