1 What is Orudis?

Brand: Orudis, Orudis KT, Oruvail

Generic: Ketoprofen

Orudis is a painkiller used to treat pain caused by certain medical conditions. Doctors prescribe Ketoprofen to treat mild to moderate pain and inflammation caused rheumatoid arthritis, osteoarthritis, gout, and dysmenorrhea.

Orudis belongs to a class of painkillers called non-steroidal anti-inflammatory agents NSAIDS. It works by lowering substances in the blood responsible for pain and inflammation in the body.

Orudis is available in extended-release capsules for the treatment of arthritis-related pain. Orudis does not have fast onset so therefore not useful in treating pain quickly.

Like most other NSAIDS, Ketoprofen has other effects like reducing blood’s ability to form clots. Ketoprofen is a prescription drug.

When used for long periods or at high doses, Ketoprofen is known to increase the risk of fatal heart attack or stroke, especially in patients with or having a history of heart disease. Ketoprofen may also promote bleeding in the stomach or intestines, which can be fatal in elderly and very sick patients.

These serious conditions can occur anytime while using Ketoprofen, often without warning. Ketoprofen must be taken only according to doctor’s instructions.

2 What to Know Before Using

Before using Orudis, you must know all about the risks and complications associated with it. Orudis must be used very cautiously in patients with heart disease. Use of Orudis may cause a heart attack or stroke, which can result in death. Anyone using Ketoprofen must be aware of the risk of stroke and heart attack, and so must take precautions.

Ketoprofen is highly contraindicated in individuals scheduled or recovering from heart bypass procedures.

Tell your doctor if you previously experienced allergies to Ketoprofen or other NSAID drugs like Aspirin, Celecoxib, and Ibuprofen. You cannot use Ketoprofen if you are allergic to it. You cannot take Ketoprofen if you are also taking the drug Probenecid.

Ketoprofen may cause bleeding in the stomach or intestines, which can result in serious internal bleeding. Bleeding can occur anytime while using Ketoprofen, often without warning. Older patients are more vulnerable to this adverse effect of Ketoprofen.

Tell the doctor if you consume large quantities of alcohol or if you are using tobacco. Tobacco and alcohol can increase the risk of Ketoprofen’s adverse effects. Tell the doctor all the medical problems you have before using Ketoprofen.

The doctor need to know if you have the following health issues:

  • Heart disease
  • If you use tobacco
  • Hypertension
  • Have low levels of albumin in the blood
  • Elevated cholesterol or triglyceride levels
  • Diabetes
  • History of forming blood clots in the bloodstream
  • Asthma
  • Nasal polyps
  • Inflammation in the mouth
  • Low sodium levels
  • Liver problems
  • Diseases affecting the kidneys
  • Fluid retention
  • In state of poor health

Do not take Ketoprofen if you are pregnant or breastfeeding. Ketoprofen is an FDA pregnancy category C drug, which means it may cause harm to the unborn baby when given to pregnant patients. Ketoprofen is especially hazardous to patients in their last 3 months of pregnancy. Do not breastfeed while receiving Ketoprofen because it may be expressed in breast milk.

The full safety and effectiveness profile of Ketoprofen in children and patients less than 18 years of age is not known.

Tell the doctor if you are drinking large quantities of alcohol before receiving Ketoprofen. Taking alcohol can increase the risk of stomach bleeding and hypertension caused by Ketoprofen. Tel

l the doctor all the medications you take before receiving Ketoprofen to prevent drug interactions.

The doctor will need to know if you are taking the following medications:

  • Adefovir
  • Anisindione
  • Apixaban
  • Ardeparin
  • Botulism immune globulin
  • Sodium biphosphate
  • Cabozantinib
  • Cidofovir
  • Cytomegalovirus immune globulin
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Dasatinib
  • Deferasirox
  • Desirudin
  • Dicumarol
  • Drotrecogin alfa
  • Edoxaban
  • Emtricatabine
  • Tenofovir
  • Efavirenz
  • Enoxaparin
  • Fondaparinux
  • Ipritumomab
  • Ibrutinib
  • Intravenous and subcutaneous immune globulins
  • Ketorolac
  • Leflunomide
  • Lomitapide
  • Methotrexate
  • Mipomersen
  • Omacetaxine
  • Ponatinib
  • Prasugrel
  • Ramucirumab
  • Respiratory syncytial virus immune globulin
  • Regorafenib
  • Rivaroxaban
  • Sirolimus
  • Tacrolimus
  • Tenofovir
  • Teroflunomide
  • Tinzaparin
  • Tositumomab
  • Warfarin

3 Proper Usage

To use Orudis properly, you must follow all instructions given by your doctor. Orudis is available in tablets that you take by mouth. Orudis comes with an extra information leaflet.

Make sure to completely understand the information in this leaflet before using Orudis. If you have questions, ask your doctor or pharmacist.

The doctor will determine your dose of Orudis:

  • For osteoarthritis and rheumatoid arthritis, Ketoprofen is usually taken 3 to 4 times a day.
  • For gout, Ketorolac is usually taken every 6 hours until the gouty attack is resolved, which happens in 2 to 3 days.
  • For pain, Ketorolac is taken every 6 to hours. For fever, Ketoprofen is taken every 4 to 6 hours; the dose can be increased if the fever does not improve within an hour.
  • For dysmenorrhea, Ketoprofen is taken every 6 to 8 hours.

Do not open, chew, break or crush extended-release Ketoprofen tablets.

The maximum dose of Ketoprofen is 300 mg per day. Always follow doctor’s instructions in receiving Ketoprofen.

Always take Ketoprofen with a full glass of water. Ketoprofen can be taken with food to reduce stomach upset, although it may not reduce the risk of bleeding in the stomach and intestines.

If you missed a dose of Ketoprofen, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and return to original dosing. Do not take two doses of Ketoprofen at once.

Taking too much Ketoprofen tablets can result in overdose, which can cause serious side effects. If this happens, call local poison control hotlines for emergency medical advice.

Store Ketoprofen in its original packaging away at room temperature away from heat, moisture and light.

4 Precautions to Take

In using Orudis, you must be careful and take some precautions as advised by your doctor. Orudis may make you drowsy and dizzy, so avoid driving or performing unsafe tasks after taking medication.

Orudis can cause stomach ulcers and bleeding, especially when taken in high doses (more than 100 mg per day), drink alcohol, or smoke tobacco. Taking Orudis with food does not appear to reduce the risk of bleeding in the digestive tract.

Call the doctor right away if you experienced:

  • unusual weight gain
  • swelling
  • severe stomach or back pain
  • passed out black tarry stools
  • vomited blood or a liquid that looks like coffee grounds

Only use Ketoprofen as directed by the doctor. Do not use less or more than the amount prescribed.

Taking other NSAID drugs (like Ibuprofen and Aspirin) with Ketoprofen increase risks of side effects. Do not take other drugs, including prescription and over-the-counter drugs, without your doctor’s advice.

The doctor will schedule you to regular clinic appointments and lab tests while you receive Ketoprofen to monitor your condition and detect early signs of side effects. Make sure to keep up with all the appointments.

Elderly patients taking Ketoprofen need close monitoring because they are more sensitive to its effects.

If you became pregnant or breastfeed while receiving Ketoprofen, call your doctor immediately.

5 Potential side effects

Orudis may cause serious side effects such as:

  • Severe allergic reaction symptoms such as
    • skin rash
    • hives
    • itching
    • difficulty breathing
    • swelling of the mouth, nose, lips or tongue
  • Infection symptoms like a sore throat, fever, and chills
  • Stroke symptoms such as
    • numbness in an arm or leg
    • one-sided weakness
    • changes in vision or speech
  • Redness, swelling, blistering or peeling of skin
  • Severe and persistent stomach or back pain
  • Ringing in the ears
  • Seizures
  • A severe headache or dizziness
  • Changes in mood or thinking
  • Sudden unexpected weight gain
  • Vomit that looks like coffee grounds, or with gross blood
  • Passing out black, tarry or grossly bloody stools
  • Changes in urine
  • Chest pain
  • Confusion
  • Swelling of the hands, arms or feet
  • Unusual joint or muscle pain
  • Unusual tiredness
  • Jaundice

Orudis may cause the following minor side effects that are not harmful to health: