1 What is Ofirmev?

Brand: Ofirmev

Generic: Acetaminophen

Ofirmev is a painkiller and antipyretic which is used for the treatment of moderate to severe pain when used alone or in combination with other drugs and for relief from fever.

It is a non-addictive painkiller thus has an advantage that its use for the long term is not associated with dependence; however, it can cause liver damage if used in large amount.

Ofirmev injection is a prescription drug which is available in the form of an injectable solution.

2 What to Know Before Using

Before using Ofirmev, you must know all about the risks and complications associated with it. The patient is the authoritative figure when it comes to any medical procedure or any drug therapy.

It is important for the patient to know all the details about the drug and the start it. Doctor also has a duty to bring out answers from the patient which play an important role in treatment like history, any allergy or any medical condition the patient has.

For this purpose, it is important to have a detailed session between patient and the physician before starting this drug to sort out all the details.

A detailed history of a patient is extremely important prior to any medical therapy and in this case, it is more likely that a drug is started after it.

Allergies or any history of allergy to any drug, food, preservatives, dyes or animal products; history of drug usage, past medical or surgical procedure should also be kept in the record to predict any drug interaction.

  • Physical examination should be done before starting this drug so that any physiological or pathological condition by which this drug may interfere may be ruled out.
  • The age-specific analysis is vital to have information about side effects of different age groups. Appropriate studies have revealed that there are no extra effects in children above 2 years of age or in geriatric patients as those of young adults. There is a lack of studies of this drug in children below 2 years of age. There are not enough studies regarding its use in pregnant women while in breastfeeding women, it has been found to have minimal effects on the patient.
  • Drug interactions are the effects of the therapy or the condition for which the drug is used by other drugs used concomitantly. It is necessary that no drug be started without consulting a physician as another drug may cause an alteration in the effect of a drug or its removal from the body. There are certain drugs which are contraindicated when used along with acetaminophen including imatinib, isoniazid, pixantrone, pneumococcal 13-valent vaccine and diphtheria conjugate. There are also some medications which are used commonly with acetaminophen and their use together leads to increase in side effects. Such drugs include acenocoumarol, carbamazepine, fosphenytoin, lixisenatide, phenytoin, warfarin and zidovudine. The patient should also ask the doctor about the effects of alcohol, tobacco, and certain foods while being on this medication.
  • Medical conditions, other than the condition for which this drug is used, may also affect the working of the drug and cause harm. It is important for the patient to give detailed history, and important for the doctor to derive such details from the patient to avoid such circumstances. The conditions which may interact with this drug include alcohol abuse, low blood volume, kidney disease, liver impairment, and malnutrition.

3 Proper Usage

To use Ofirmev properly, you must follow all instructions given by your doctor. Ofirmev injection is given in the form of infusion over 15 minutes.

It is given by a nurse or any other paramedic through the venous route. Few doses of this injection are given and when the conditions improve, the patient is shifted to oral medication.

4 Precautions to Take

In using Ofirmev, you must be careful and take some precautions as advised by your doctor. Precautions are the part and parcel of any treatment and patient must adhere to these to improve the outcome.

It is the duty of the doctor or any medical care provider to make the patient aware of these tips as an aid to the therapy.

  • Observation by a doctor, when the drug is being given, is necessary to make sure if the drug is working or not.
  • Consult your doctor if there is any suspicion of liver damage.
  • Anaphylaxis may occur as an allergic reaction to the drug. It is a medical emergency and patient should be rushed to the hospital.
  • Serious skin reactions may occur with this drug and it is important to consult your doctor about any such change.
  • Do not use alcohol while being on this drug.
  • Alcohol and CNS depressants’ effects will be boosted by this drug and it is important to avoid these during this therapy.
  • Do not overdose the drug above 4 grams per day.
  • Store the drug in a dry place at room temperature. Keep it away from the reach of children.

5 Potential Side Effects

There is no drug in the world which is without its unwanted effects. Make sure you meet with your doctor in using Ofirmev to avoid unwanted potential side effects.

Some drugs are relatively safe for use while for some drug, the patient should be cautious as these drugs may cause more harm than good. The patient should always get medical help in case of any adverse effect, no matter how much trivial it is.

Some side effects associated with Ofirmev injection include:

  • Abnormal breath sounds
  • Swelling of face or limbs
  • Labored breathing
  • Difficulty opening the mouth
  • Dizziness or lightheadedness when getting up suddenly from a lying or sitting position
  • Irregular heartbeat
  • Lockjaw
  • Loss of appetite
  • Muscle pain
  • Muscle spasm
  • Nausea or Vomiting
  • Nervousness
  • Numbness or Tingling sensation
  • Pain at the injection site
  • Sweating
  • Chest tightness
  • Unusual tiredness
  • Decreased urination
  • Abdominal pain
  • Tenderness
  • Clay-colored stools
  • Dark urine
  • Decreased appetite
  • Difficulty swallowing
  • Flu-like symptoms

Symptoms associated with overdose include:

  • Black tarry stools
  • Bleeding gums
  • Bloating of the abdomen
  • Blood in the urine or stools
  • Chills
  • Difficult or painful urination
  • General feeling of discomfort
  • Pinpoint red spots on the skin
  • Sudden decrease in the amount of urine
  • Unpleasant breath odor
  • Vomiting of blood